The reversible Hill equation: how to incorporate cooperative enzymes into metabolic models

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The reversible Hill equation: how to incorporate cooperative enzymes into metabolic models

MOTIVATION Realistic simulation of the kinetic properties of metabolic pathways requires rate equations to be expressed in reversible form, because substrate and product elasticities are drastically different in reversible and irreversible reactions. This presents no special problem for reactions that follow reversible Michaelis-Menten kinetics, but for enzymes showing cooperative kinetics the ...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 1997

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/13.4.377